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Cosmelan Pack MD*

Original price $1,300.00 - Original price $1,300.00
Original price
$1,300.00 - $1,300.00
Current price $1,300.00

*In order to purchase this product you must also schedule a Virtual Consultation.

Professional depigmenting treatment designed to reduce dark spots and unify the skin tone and enhancing skin luminosity.

Cosmelan is a depigmenting with an intensive corrective effect that regulates the overproduction of melanin in the melanocytes, inhibiting and controlling the appearance of new sunspots. It has a dual controlling and corrective action achieving short and long-term results by keeping hyperpigmentation under control. Cosmelan MD is a medical grade formulation that has proven to show results as soon as two weeks post-treatment.

This product also includes Hydroquinone, a dermatologist-recommended ingredient to safely fade dark spots.

The Cosmelan Method consists of 4 phases.

  1. Phase I: Intensive Depigmentation 
  2. Phase II: Continuous Depigmentation
  3. Phase III: Pigmentation Regulation 
  4. Phase IV: Reappearance Control 

Cosmelan contains an exclusive combination of active substances with proven efficacy, which act on all phases of the hyperpigmentation process eliminating existing hyperpigmentation, preventing its reappearance and also stopping the appearance of new dark spots. It is an all-round effective result.

trust the leader

the world's leading professional

depigmentation method


Proven efficacy

Efficacy tests support its results in any
skin phototype (I-VI) and in all ethnicities

High satisfaction

Excellent long-term results and high satisfaction for patients

+ 1 million patients

More than 1 million patients treated

International presence

Distributed on 5 continents

Satisfied professionals

Thousands of professionals already use cosmelan and recommend it to their patients

1. The problem: dark spots

Pigmentation concerns are a growing, global issue; they affect more than 90% of adults over the age of 50. Regardless of skin colour they are a significant issue because of their unattractive appearance and negative impact at psycho-emotional level and affecting the quality of life.

Skin hyperpigmentation is caused by abnormal production of melanin, the pigment responsible for skin colour, and a consequence of uncontrolled, localised overproduction of melanin inside the melanocyte, which causes irregular skin colouration, and dark spots.

Numerous external and internal factors can cause hyperpigmentation:


Sun exposure




Exposure to


Types of hyperpigmentation and their diagnosis




sloar lentigo
senile lentigo



What triggers it?

How does it look like?

Shape and distribution:

Uneven and irregular with undefiend edges. Frequently symmetrical. Shadow-like appearance.

Appearance under UV light:

  • Superficial-medium depth: darker under UV light.
  • Medium-deep depth: disappear totally or partly under UV light.

Often mixed.

Shape and distribution:

Irregular spots, asymmetric, flat, dark, pigmentation, localised or dispersed.

Appearance under UV light:

  • Superficial-medium depth: dark tones, define borders.
  • Medium-deep depth: dark tone without defined edges.

Shape and distribution:

Oval or round spots, lentil-shaped, even, measuring 2-20 millimetres.

Appearance under UV light:

More intense colour with perfectly defined shape

Shape and distribution:

Small, flat, pigmented spotes. Multiple and symmetrical. Light brown.

Appearance under UV light:

More intense colour with perfectly defined shape

Where do they appear?

facial centre







shoulders, arms, back and décolletage


décolletage and back of arms

Who suffers from them?

90% women, particularly:

  • Pregnant women.
  • Users of oral
  • Users of hormone
    replacement therapy

More common in dark
phototypes. After skin
lesions (acne or dermatitis),
injury (burns, surgery,
trauma), beauty treatments
(chemical peels, laser),
upper lip depilation,

Senile lentigo persons
+ 50 years, due to the accumulated effect of the sun. 

Solar lentigo: from
30 years, often in low
phototype skins

Common in low
phototypes, with fair skin
and blonde or red hair.
Highly sensitive to UV

2. The solution: the cosmelan® method

The cosmelan® method: what is it?

cosmelan® is a depigmenting method with an intensive corrective effect that regulates overproduction of melanin in the melanocytes,
inhibiting and controlling the appearance of new dark spots. It has a dual corrective and controlling action, achieving short and
long-term results by keeping hyperpigmentation under control.
The method comprises 4 treatment phases, and its full compliance ensures excellent results for patients

Phase 1


Phase 2


Phase 3


Phase 4


Phase 1


Phase 2


Phase 3


Phase 4


Phase 1


Phase 2


Phase 3


Phase 4


oil removing
solution (*) 

cosmelan 1
facial mask (*)

in office treatment

cosmelan 2
cream (*) 

factor k (*) 

moisturising sun
protection SPF 50+

in home treatment

This dual corrective and regulating action makes it a unique, all-round treatment

The cosmelan® method: the formula, how does it work? 

cosmelan contains an exclusive combination of active substances with proven efficacy, which act on all phases of the hyperpigmentation process totally eliminating existing hyperpigmentation, preventing its reappearance and also stopping the
appearance of new dark spots. An all-round, effective result.

3. The cosmelan® method products

In office treatment

The method is started in office, by a professional

oil removing solution

10 ml

This solution removes excess oil from the stratum corneum to facilitate active substances penetration and improve the efficacy of the treatment for an all-over result.

Instructions for use: Apply to clean, dry skin with a gauze.

mesoestetic recommends:

  • Previous cleanse of the affected area prepares the skin for treatment
  • After cleansing, protect the sensitive areas around the eyes and lips by applying a protective film of mesolips protector.

cosmelan 1 facial mask

10 g

cosmelan 1 works effectively on existing melanin, degrading and eliminating dark spots while inhibiting the melanin formation process. This prevents recurrence and the appearance of new spots.

Instructions for use: apply a thick layer of cosmelan 1 facial mask, and and leave it on. The professional decides how long to leave the product in place. Avoid the eye contour area.

Application times of cosmelan 1:

mesoestetic recommended application times for guidance purposes only

mesoestetic recommends:

  • The mask application time depends on the skin phototype, sensitivity and the condition of the skin to treat. This is determined by the professional.
  • The intensity of the treatment depends on the thickness of the layer of product applied. For optimal efficacy, we recommend applying all the product, 10 g.
  • Apply the mask evenly and all over the face, not just to hyperpigmented areas.
  • Keep the mask moist while in place to prevent cracking. Use a water spray to do this, without removing the product.

Once the mask has been applied the patient can go home. During the application time and after removing the mask, the patient must avoid exposure to sources of light and heat.

After the time prescribed by the professional is over, the patient must remove the cosmelan 1 mask at home, carefully cleansing the application area with plenty of lukewarm water. Never exceed the recommended application time.

At home

48 hours after removing the mask, the method continues at home. The patient must follow the Instructions for use to ensure the desired result. Home care products:

cosmelan 2 cream

30 g

cosmelan 2 cream boosts the depigmenting result of cosmelan 1, keeping the production of new melanin under control, preventing the reappearance of the dark spots treated and controlling the appearance of new spots.

Instructions for use: apply cosmelan 2 on clean, dry skin, massaging in gently, according to the Instructions for use in the “cosmelan method protocol” on the following page.

mesoestetic recommends:

  • Patients not adhering to the recommendations may see the reappearance of existing dark spots or the appearance of new spots and the effect not last.
  • Patients often describe a sensation of heat and stinging. This is to be expected and is a sign that the method is working. This can be relieved by applying cool air to the face.

hydra-vital factor k

50 ml

Moisturising, soothing product that restores balance to the skin barrier after treatments such as cosmelan, when skin loses its natural protection due to intensive scaling.

Instructions for use: massage in gently until fully absorbed, always after cosmelan 2.

mesoestetic recommends:

  • While applying cosmelan 2 it is normal to feel the skin tight and dry. Apply hydra-vital factor k as often as necessary. For an intensive effect, apply a thick layer of the product to face and wait until complete absorption.

moisturising sun protection SPF 50+

50 ml

Moisturising, antioxidant sun protection, which provides efficient protection from UV radiation, the main cause of dark spots. It contains extremely efficient, safe sun filters for use during the cosmelan method.

Instructions for use: apply after hydra-vital factor k, and before contact with sunlight. Reapply in case of continuous exposure to sunlight.

mesoestetic recommends:

  • UV protection is essential throughout the cosmelan treatment. If UV protection is not used, the treatment will not be as effective and dark spots may reappear. We recommend using moisturising sun protection which contains UV filters that do not cause itching or burning, while other, chemical-based sun filters may cause these reactions. Reapply every 3-4 hours in case of direct exposure to the sun.

4. The cosmelan® method protocol

5. Additional recommended treatments

In office

mesopeel melanostop

50 ml

In cases of severe hyperpigmentation, or to boost the results of cosmelan, professionals may consider using a peel in advance to inhibit melanogenesis in hyperactive melanocytes.

Instructions for use: use the peel at least 48 hours before treatment with cosmelan.

post-peel crystal fiber mask

5 x 25 ml

Latest-generation face mask designed to enhance the cell renewal process, restructure the water-lipid layer and increase skin moisture levels.

Instructions for use: apply the mask and allow to work for about 20 minutes.

At home

melanogel touch

15 ml

For localised hyperpigmentation, melanogel touch roll-on is a suitable solution. It inhibits melanin-producing enzymatic mechanisms, optimising the whitening effect on cutaneous hyperchromia.

Instructions for use: Apply locally on the dark spot and repeat throughout the day.

post-procedure fast skin repair

50 ml

In case of intense erythema or irritation, we recommend alternating the use of hydra-vital factor k with fast skin repair cream, which has regenerative. The formula encourages reepithelisation and healing of tissues damaged by the treatment.

Instructions for use: apply after cosmelan 2, massaging in gently until fully absorbed. Finish the treatment by applying moisturising sun protection SPF 50+.


Laser is a commonly used, highly effective treatment for skin hyperpigmentation. It is particularly effective for low and medium phototype skins (I-III) where hyperpigmentation is more visible on the skin surface. Even so, the professional must recommend a maintenance treatment to the patient to prevent the reappearance of the spots. The combination of laser treatment and the “cosmelan method” home maintenance regime makes the treatment more successful, by correcting and controlling excess melanin production; providing both a short and long-term solution.

In higher phototypes (IV-VI), laser is less effective and the likelihood of triggering an HIP is higher. In such cases, the home method should be used before and after laser treatment to keep the dark spots under control. Moreover, in patients at high risk of PIH, we recommend you consider using the cosmelan method rather than laser, which is better tolerated, more efficient and involves a lower risk of recurrence and a longer-lasting result.

6. The results of the cosmelan® method

The efficacy of the cosmelan method has been demonstrated in specific in vitro and in vivo studies under medical supervision.

In vivo results: phototypes I - III

In vivo results: phototypes IV - VI

Measurement of in vivo results

In in vivo studies, pigment reduction in the spot was measured during treatment with the cosmelan method:

* Melanin index: measured with MPA580 mexameter probe (Courage Khazaka electronic GmbH). Melanin measurement in hyperpigmented area.

** MASI: (MASI score: Melasma Area and Severity Index) is an specific a measuring system to evaluate melasma severity. It consists of assessing four specific areas: forehead, malar (cheekbone) (left and right) and chin. A subjective score is assigned to determine the melasma severity. These assessments were always made by same professional.

Results of in vitro studies

The capacity of the active substances in the cosmelan method to inhibit melanin production was assessed in vitro in melanocyte cultures.

-81% of melanin synthesis at 48 hours:

An 81% reduction in melanin levels in a melanocyte culture, and effective inhibition of melanin synthesis was measured after 48 hours of exposure to the active substances in the cosmelan method.

mesoestetic Pharma Group is a world leading pharmaceutical manufacturer in the medical cosmetics sector.

Committed to promoting health and fostering initiatives with high social impact that protect and improve quality of life.

Committed to using innovative technologies and constantly carrying out R&D that leads to efficient solutions for patients’ needs, particularly projects to prevent and treat skin disorders.

committed to healthy skin

Customer Reviews

Based on 3 reviews

Please don't order stuff and service bad customer service bought stuff ,paid attractive arrive on time came 1 week late..called many times ..only they say..ok hmm ok .. not professional. One star for your service

Zahira R.

I applied cosmelan once and the incredible results, the skin on my face changes 100% more soft and healthy and the spots on my face are now lighter... i recommend COSMELAN

Cosmelan peel

This peel gave me amazing results for my oily skin